Binding antibody levels to vaccine (HPV6/11/16/18) and non-vaccine (HPV31/33/45/52/58) HPV antigens up to 7 years following immunization with either Cervarix® or Gardasil® vaccine
| Autor: | Kavita Panwar, Anna Godi, Clementina E. Cocuzza, Nick Andrews, Jo Southern, Paul Turner, Elizabeth Miller, Simon Beddows |
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| Přispěvatelé: | Panwar, K, Godi, A, Cocuzza, C, Andrews, N, Southern, J, Turner, P, Miller, E, Beddows, S |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Human papillomavirus
Adolescent General Veterinary General Immunology and Microbiology Papillomavirus Infections Vaccination Public Health Environmental and Occupational Health 06 Biological Sciences Antibodies Viral Antibodies Neutralizing Durability Infectious Diseases Human papillomaviru Human Papillomavirus Recombinant Vaccine Quadrivalent Types 6 11 16 18 Virology 07 Agricultural and Veterinary Sciences Humans Molecular Medicine Female Papillomavirus Vaccines Child Vaccine 11 Medical and Health Sciences Antibody |
| Popis: | Human Papillomavirus (HPV) bivalent (Cervarix®) and quadrivalent (Gardasil®) vaccines demonstrate robust efficacy against vaccine types and cross-protection against related non-vaccine types. Here we evaluate the breadth, magnitude and durability of the vaccine-induced antibody response against vaccine (HPV6/11/16/18) and non-vaccine (HPV31/33/45/52/58) type antigens up to 7 years following vaccination of 12-15 year old girls in a three dose schedule and contrast these data with the levels of antibody typically seen in natural infection. Vaccine-type antibody levels waned over the 7-year follow up period but remained at least an order of magnitude above the typical antibody levels elicited by natural infection. Seropositivity to non-vaccine types remained high 7 years after initial vaccination, but antibody levels approached those typically generated following natural infection. Empirical data on the breadth, magnitude, specificity and durability of the immune response elicited by the HPV vaccines contribute to improving the evidence base supporting this important public health intervention. |
| Databáze: | OpenAIRE |
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