Formation of Dihydronaphthalenes via Organocatalytic Enatioselective Michael–Aldol Cascade Reactions with Arylalkanes
| Autor: | Xiangmin Li, Sinan Wang, Hao Li, Tengfei Li, Jian Li, Wei Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Aldehydes Molecular Structure Stereochemistry organic chemicals Organic Chemistry Enantioselective synthesis Stereoisomerism Naphthalenes Crystallography X-Ray Ring (chemistry) Biochemistry Combinatorial chemistry Catalysis Deprotonation Nucleophile Aldol reaction chemistry Cascade Alkanes Nitro heterocyclic compounds Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic Letters. 15:5634-5637 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | An organocatalytic highly enantioselective Michael-aldol cascade access to valuable chiral dihydronaphthalenes has been realized. Notably, the strategy via activation of nucleophilic alkyl chains by introducing nitro, chloro, or CF3 group(s) at the ortho- and/or para-position(s) on an aromatic ring renders them readily deprotonated to produce highly reactive nulecophilic species in the cascade process under mild conditions. |
| Databáze: | OpenAIRE |
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