Burden and consequence of birth defects in Nepal-evidence from prospective cohort study
| Autor: | Rejina Gurung, Avinash K Sunny, Ashish Kc, Abhishek Gurung, Nawaraj Kc, Ram Narayan Chaudhary, Netra Rana, Prajwal Paudel, Honey Malla |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Cleft Lip 030105 genetics & heredity Logistic regression Pediatrics Odds 03 medical and health sciences Young Adult 0302 clinical medicine Nepal Pregnancy Risk Factors Anencephaly medicine Prevalence Humans 030212 general & internal medicine Prospective Studies Risk factor Mortality Prospective cohort study Asphyxia Obstetrics business.industry Infant Newborn lcsh:RJ1-570 Pediatrik Public Health Global Health Social Medicine and Epidemiology lcsh:Pediatrics Odds ratio medicine.disease Cleft Palate Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Neonatal infection Birth defects Case-Control Studies Pediatrics Perinatology and Child Health Female medicine.symptom business Research Article |
| Zdroj: | BMC Pediatrics, Vol 21, Iss 1, Pp 1-8 (2021) BMC Pediatrics |
| ISSN: | 1471-2431 |
| Popis: | BackgroundEvery year an estimated 7.9 million babies are born with birth defect. Of these babies, more than 3 million die and 3.2 million have disability. Improving nationwide information on prevalence of birth defect, risk factor and consequence is required for better resource allocation for prevention, management and rehabilitation. In this study, we assess the prevalence of birth defect, associated risk factors and consequences in Nepal.MethodThis is a prospective cohort study conducted in 12 hospitals of Nepal for 18 months. All the women who delivered in the hospitals during the study period was enrolled. Independent researchers collected data on the social and demographic information using semi-structured questionnaire at the time of discharge and clinical events and birth outcome information from the clinical case note. Data were analyzed on the prevalence and type of birth defect. Logistic regression was done to assess the risk factor and consequences for birth defect.ResultsAmong the total 87,242 livebirths, the prevalence of birth defects was found to be 5.8 per 1000 live births. The commonly occurring birth defects were anencephaly (3.95%), cleft lip (2.77%), cleft lip and palate (6.13%), clubfeet (3.95%), eye abnormalities (3.95%) and meningomyelocele (3.36%). The odds of birth defect was higher among mothers with age ConclusionMaternal age younger than 20 years and advantaged ethnicity were risk factors of birth defects. Babies with birth defect have high risk for birth asphyxia, neonatal infection and pre-discharge mortality at birth. Further evaluation on the care provided to babies who have birth defect is warranted.FundingSwedish Research Council (VR). |
| Databáze: | OpenAIRE |
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