Low levels of minimal residual disease after induction chemotherapy for BCR‐ABL1 ‐negative acute lymphoblastic leukaemia in adults are clinically relevant
| Autor: | Štěpán Hrabovský, Cyril Šálek, Pavla Pecherkova, Petr Cetkovský, Hana Jelínková, Eva Froňková, František Folber, Michael Doubek, Jiří Mayer, Jan Trka, Jan M. Horáček |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Neoplasm Residual Multivariate analysis Fusion Proteins bcr-abl Disease BCR/ABL1 Negative 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Humans Medicine Proportional Hazards Models biology business.industry Hazard ratio Age Factors Disease Management Induction chemotherapy Induction Chemotherapy Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Minimal residual disease 3. Good health Consolidation Chemotherapy Treatment Outcome 030220 oncology & carcinogenesis biology.protein Lymphoblastic leukaemia Female Antibody business 030215 immunology |
| Zdroj: | British Journal of Haematology. 196:706-710 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.17966 |
| Popis: | The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74·0%, 42·3% and 35·0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0·32 and 2·25). |
| Databáze: | OpenAIRE |
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