LDL receptor mutations and ApoB mutations are not risk factors for ischemic cerebrovascular disease of the young, but lipids and lipoproteins are
| ISSN: | 1351-5101 |
|---|---|
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc60f7a2b202770fc375448435fb16c https://pubmed.ncbi.nlm.nih.gov/10529757 |
| Rights: | CLOSED |
| Přírůstkové číslo: | edsair.doi.dedup.....7cc60f7a2b202770fc375448435fb16c |
| Autor: | Henrik Jensen, Peter Arlien-Søborg, Ruth Frikke-Schmidt, Sixtus Thorsen, Sissel Vorstrup |
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Apolipoprotein B Lipoproteins DNA Mutational Analysis Familial hypercholesterolemia Disease Logistic regression Brain Ischemia chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus medicine Humans Apolipoproteins B Univariate analysis biology Cholesterol business.industry Age Factors Cerebral Arteries Middle Aged medicine.disease Lipids Cerebrovascular Disorders Endocrinology Neurology chemistry Receptors LDL LDL receptor biology.protein lipids (amino acids peptides and proteins) Female Neurology (clinical) business |
| Zdroj: | European journal of neurology. 6(6) |
| ISSN: | 1351-5101 |
| Popis: | BACKGROUND The genetic background for ischemic cerebrovascular disease of the young and the role of lipids and lipoproteins as risk factors are not clear. METHODS We determined five LDL receptor mutations (Trp23Stop, Trp66Gly, Trp556Ser, 313+1G --> A, 1846-1G --> A) and three apolipoprotein B mutations (Arg3500Gln, Arg3500Trp, Arg3531Cys), and other risk factors for ischemic cerebrovascular disease in 80 patients (36 women, 44 men) with onset of disease before the age of 50 years compared with 3366 individuals from a general population sample within the same age range. RESULTS None of the patients were carriers of mutations in the LDL receptor (Trp23Stop, Trp66Gly, Trp556Ser, 313+1G --> A, 1846 - 1G --> A) or the apolipoprotein B gene (Arg3500Gln, Arg3500Trp, Arg3531Cys) associated with hypercholesterolemia. However, on univariate analysis as well as on logistic regression analysis allowing for age and gender, plasma cholesterol (OR 1.4; P < 0.0005), HDL-cholesterol (OR 0.4; P < 0.005), diabetes (OR 5.8; P < 0.0001), and hypertension (OR 3.9; P < 0.001) were significant predictors of ischemic cerebrovascular disease. CONCLUSIONS The five most common LDL receptor mutations in Danish patients with familial hypercholesterolemia and three mutations in the apolipoprotein B gene did not predispose to ischemic cerebrovascular disease of the young. However, cholesterol and HDL-cholesterol are important risk factors for ischemic cerebrovascular disease of the young in the present study. The elevation in cholesterol could in some patients be due to rare LDL receptor mutations not tested for, and could in other patients be multifactorial in origin. |
| Databáze: | OpenAIRE |
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