Omega-3 Fatty Acid Effect on Alveolar Bone Loss in Rats
| Autor: | Dolph Dawson, M. J. Steffen, B. Raghu, J. L. Ebersole, B. Vasudevan, Arunabh Bhattacharya, Gabriel Fernandes, J. M. Novak, M. C. Correll, L. Kesavalu, E. Browning |
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| Rok vydání: | 2006 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Alveolar Bone Loss Biology Article Rats Sprague-Dawley 03 medical and health sciences Fish Oils 0302 clinical medicine Internal medicine Fatty Acids Omega-3 Bacteroidaceae Infections medicine Animals Omega 3 fatty acid General Dentistry Porphyromonas gingivalis Dental alveolus Analysis of Variance 030102 biochemistry & molecular biology Fatty Acids 030206 dentistry Fish oil biology.organism_classification Eicosapentaenoic acid Rats Resorption Radiography Endocrinology Docosahexaenoic acid Dietary Supplements Immunology Female Corn oil |
| Zdroj: | Journal of Dental Research. 85:648-652 |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/154405910608500713 |
| Popis: | Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (ω)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (ω-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the ω-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with ω-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an ω-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that ω-3 FA may be a useful adjunct in the treatment of periodontal disease. Abbreviations: PUFA, polyunsaturated fatty acid; EPA, eicosapentanoic acid; DHA, docosahexanoic acid; and PCR, polymerase chain-reaction. |
| Databáze: | OpenAIRE |
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