Rash after measles vaccination: laboratory analysis of cases reported in São Paulo, Brazil
| Autor: | Raymundo Soares Azevedo, Cristina Adelaide Figueiredo, Márcia Theobaldo, Maria Isabel de Oliveira, Suely Pires Curti, Ana Afonso, Edison Luiz Durigon |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Pediatrics Herpesvirus 6 Human viruses Antibodies Viral medicine.disease_cause Polymerase Chain Reaction Parvovírus humano B19 Parvovirus B19 Human biology lcsh:Public aspects of medicine virus diseases Rubella virus Rash Vaccination Rubella Infection Female medicine.symptom Human parvovirus B19 Brazil Measles vaccination medicine.medical_specialty Measles Vaccine Enzyme-Linked Immunosorbent Assay Rubella Measles Parvoviridae Infections Measles virus Vacinação do sarampo Exantema medicine Humans Rubéola business.industry Infant Newborn Public Health Environmental and Occupational Health Infant lcsh:RA1-1270 Exanthema biology.organism_classification medicine.disease Herpes vírus humano 6 Immunoglobulin M Sarampo Human herpes virus 6 Measles vaccine business |
| Zdroj: | Revista de Saúde Pública v.36 n.2 2002 Revista de Saúde Pública Universidade de São Paulo (USP) instacron:USP Revista de Saúde Pública, Vol 36, Iss 2, Pp 155-159 (2002) Revista de Saúde Pública, Vol 36, Iss 2, Pp 155-159 |
| ISSN: | 0034-8910 |
| DOI: | 10.1590/s0034-89102002000200006 |
| Popis: | OBJECTIVE: The clinical differential diagnosis of rash due to viral infections is often difficult, and misdiagnosis is not rare, especially after the introduction of measles and rubella vaccination. A study to determine the etiological diagnosis of exanthema was carried out in a group of children after measles vaccination. METHODS: Sera collected from children with rash who received measles vaccine were reported in 1999. They were analyzed for IgM antibodies against measles virus, rubella virus, human parvovirus B19 (HPV B19) using ELISA commercial techniques, and human herpes virus 6 (HHV 6) using immunofluorescence commercial technique. Viremia for each of those viruses was tested using a polimerase chain reaction (PCR). RESULTS: A total of 17 cases of children with exanthema after measles immunization were reported in 1999. The children, aged 9 to 12 months (median 10 months), had a blood sample taken for laboratory analysis. The time between vaccination and the first rash signs varied from 1 to 60 days. The serological results of those 17 children suspected of measles or rubella infection showed the following etiological diagnosis: 17.6% (3 in 17) HPV B19 infection; 76.5% (13 in 17) HHV 6 infection; 5.9% (1 in 17) rash due to measles vaccine. CONCLUSIONS: The study data indicate that infection due to HPV B19 or HHV 6 can be misdiagnosed as exanthema due to measles vaccination. Therefore, it is important to better characterize the etiology of rash in order to avoid attributing it incorrectly to measles vaccine. |
| Databáze: | OpenAIRE |
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