Suppression of murine IgE responses with ovalbumin-pullulan conjugates: comparison of the suppressive effect of different conjugation methods and different molecular weights of pullulan
| Autor: | Tyoku Matuhasi, Masashi Kurimoto, Hakuo Ikegami, Seishiro Naito, Tetsuya Uchida, Shunsaku Ando, Mitsuko Usui, Masakazu Mitsuhashi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Ovalbumin
Immunology Immunoglobulin E Polysaccharide chemistry.chemical_compound Mice Structure-Activity Relationship Immune Tolerance Immunology and Allergy Animals Glucans chemistry.chemical_classification biology Molecular mass Pullulan General Medicine respiratory system Molecular Weight chemistry Biochemistry Humoral immunity biology.protein Glycoprotein Conjugate |
| Zdroj: | International archives of allergy and immunology. 102(3) |
| ISSN: | 1018-2438 |
| Popis: | Ovalbumin (OVA)-pullulan conjugates were made using four different conjugation methods and eight different molecular weights of pullulan ranging from 4,200 to 600,000. Pretreatment of mice by the administration of conjugates made by using cyanulic chloride or cyanogen bromide and pullulan of molecular weight 40,000 or more, anti-OVA IgE antibody response was suppressed completely and anti-OVA IgM and IgG antibody response was enhanced. In contrast, by the administration of conjugates made by using an oxidation or thiol activation method, only partial suppression of anti-OVA IgE antibody response was achieved and no enhancement of anti-OVA IgM and IgG antibody production was observed. |
| Databáze: | OpenAIRE |
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