Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma
| Autor: | Matthias Eckhardt, Carsten Schelp, D von Schweinitz, S Glüer, Rita Gerardy-Schahn, Norbert Madry |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Neuroblastoma cell chemistry.chemical_compound Neuroblastoma medicine Biomarkers Tumor Humans Child Neural Cell Adhesion Molecules business.industry Cell adhesion molecule Embryogenesis Infant medicine.disease Sialic acid Neoplasm Proteins Oncology chemistry nervous system Child Preschool Cancer research Sialic Acids Immunohistochemistry Neural cell adhesion molecule Female business Childhood Neuroblastoma Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Neuroblastoma cells express the polysialylated form of the neural cell adhesion molecule (NCAM), which normally becomes restricted to a few neural tissues after embryogenesis. In this study, we investigated serum levels of polysialylated NCAM in 14 children with different grades and stages of neuroblastoma using an immunoluminescence assay, and compared the results to 269 healthy control subjects. Simultaneously, the polysialylated NCAM content of the tumours was determined by immunohistochemistry. Serum levels were dramatically elevated (more than sixfold) in children with advanced stages and fatal courses of disease, whereas children with differentiated tumour types and limited disease had low or normal levels. Serum concentrations correlated with the polysialylated NCAM content of the tumours, and they decreased during successful therapy. We therefore suggest polysialylated NCAM to be a useful marker monitoring childhood neuroblastoma. Images Figure 2 Figure 3 |
| Databáze: | OpenAIRE |
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