Self-Assembly Engineering Nanodrugs Composed of Paclitaxel and Curcumin for the Combined Treatment of Triple Negative Breast Cancer
| Autor: | Yan Zhang, Jing Wang, Xianquan An, Zhenyu Wang, Xiao Zheng, Shu-ting Zuo, Dan Shao |
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| Rok vydání: | 2021 |
| Předmět: |
Histology
medicine.medical_treatment Biomedical Engineering Bioengineering chemistry.chemical_compound paclitaxel Breast cancer Combined treatment medicine curcumin Cytotoxicity Triple-negative breast cancer Original Research Chemotherapy business.industry Bioengineering and Biotechnology self-assembly medicine.disease Systemic toxicity nanodrug Paclitaxel chemistry Cancer research Curcumin triple-negative breast cancer business TP248.13-248.65 Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
| ISSN: | 2296-4185 |
| Popis: | The clinical outcomes of triple-negative breast cancer (TNBC) chemotherapy are unsatisfactory. Water solubility and biosafety of chemo drugs are also major barriers for achieving satisfactory treatment effect. In this study, we have reported a combinational strategy by self-assembly engineering nanodrugs PC NDs, which were composed of paclitaxel (PTX) and curcumin (Cur), for effective and safe TNBC chemotherapy. PC NDs were prepared through reprecipitation method without using any additional carriers. The PC NDs were preferentially taken up by TNBC cells and we also observed pH-related drug release. Compared with free PTX and simple PTX/Cur mixture, PC NDs have shown higher therapeutic efficiency and better prognosis while the metastasis rate was significantly lower than that of either PTX or PTX/Cur mix group. Therefore, the self-assembly engineered PC NDs might be a promising nanodrugs for efficient and safe TNBC chemotherapy. |
| Databáze: | OpenAIRE |
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