Current progress in bionanomaterials to modulate the epigenome
| Autor: | Anna D. Y. Rhodes, Jose Antonio Duran-Mota, Nuria Oliva |
|---|---|
| Přispěvatelé: | Imperial College London |
| Rok vydání: | 2022 |
| Předmět: |
HALLMARKS
Technology Materials Science Biomaterials FIBROBLASTS Science & Technology SURFACE 0304 Medicinal and Biomolecular Chemistry 1004 Medical Biotechnology Materials Science Biomedical Engineering DNA-METHYLATION MATRIX ELASTICITY STIFFNESS Biocompatible Materials REPLICATIVE SENESCENCE 0601 Biochemistry and Cell Biology MESENCHYMAL STEM-CELLS EPIGENETICS Epigenesis Genetic Nanostructures Epigenome DIFFERENTIATION Neoplasms Humans General Materials Science |
| Zdroj: | Biomaterials science. 10(18) |
| ISSN: | 2047-4849 |
| Popis: | Recent advances in genomics during the 1990s have made it possible to study and identify genetic and epigenetic responses of cells and tissues to various drugs and environmental factors. This has accelerated the number of targets available to treat a range of diseases from cancer to wound healing disorders. Equally interesting is the understanding of how bio- and nano-materials alter gene expression through epigenetic mechanisms, and whether they have the potential to elicit a positive therapeutic response without requiring additional biomolecule delivery. In fact, from a cell’s perspective, a biomaterial is nothing more than an environmental factor, and so it has the power to epigenetically modulate gene expression of cells in contact with it. Understanding these epigenetic interactions between biomaterials and cells will open new avenues in the development of technologies that can not only provide biological signals (i.e. drugs, growth factors) necessary for therapy and regeneration, but also intimately interact with cells to promote the expression of genes of interest. This review article aims to summarise the current state-of-the-art and progress on the development of bio- and nanomaterials to modulate the epigenome. |
| Databáze: | OpenAIRE |
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