Assessment of Vascular Change Using Swept-Source Optical Coherence Tomography Angiography: A New Theory Explains Central Visual Loss in Behcet’s Disease
| Autor: | Sritatath Vongkulsiri, Sasivarin Luangpitakchumpol, Peranut Chotcomwongse, Korrawan Jaisuekul, Thanapong Somkijrungroj, Wijak Kongwattananon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Article Subject Behcet's disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Ophthalmology Optical coherence tomography Ophthalmology medicine medicine.diagnostic_test business.industry Retinal Optical coherence tomography angiography medicine.disease Fluorescein angiography eye diseases Surgery chemistry lcsh:RE1-994 030221 ophthalmology & optometry medicine.symptom business Perfusion 030217 neurology & neurosurgery Uveitis Research Article |
| Zdroj: | Journal of Ophthalmology Journal of Ophthalmology, Vol 2017 (2017) |
| ISSN: | 2090-004X |
| DOI: | 10.1155/2017/2180723 |
| Popis: | Objective. To evaluate retinal vascular structural change in ocular Behcet’s using optical coherence tomography angiography (OCTA) and fluorescein angiography (FA). Methods. An analytic cross-sectional study of 37 eyes of 21 Behcet’s uveitic patients was performed. Foveal retinal thickness (FRT), perifoveal hypoperfusion areas in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were measured with swept-source optical coherence tomography and OCTA. FA images were used for assessing the vascular features and correlation. Results. Twenty-one patients were enrolled (52.4% males). The average age at onset was 36.7 ± 12.93 years. The median of disease duration was 5 years (1–25). FRT was 118.1 ± 52.35 μm, which correlated with visual acuity (95% CI −60.47, −13.92). Using OCTA, the area of hypoperfusion in SCP (0.47 ± 0.17 mm2) was smaller than that in DCP (1.94 ± 3.87 mm2) (p<0.001). Superficial to deep capillary plexus nonperfusion (SCP : DCP) ratio was 0.57 ± 0.27 which had the positive coefficient correlation with visual acuity (95% CI −0.644, −0.015). Conclusions. OCTA is an alternative noninvasive method to monitor macular ischemia in Behcet. Behcet’s uveitis affects DCP more than SCP. Decreasing SCP : DCP ratio and decrease FRT correlates with poor visual acuity. Macular ischemia and DCP loss can be found early and can explain vision loss in Behcet. |
| Databáze: | OpenAIRE |
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