Multiple Cases of Life-threatening Adenovirus Pneumonia in a Mental Health Care Center
| Autor: | Maria Pia Sanchez, Linda A. Curtin, Béla T. Mátyás, James R. Klinger, Margaret Durkin |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Hospitals Psychiatric Male Pulmonary and Respiratory Medicine medicine.medical_specialty ARDS Adenoviridae Infections Critical Illness Pneumonia Viral Critical Care and Intensive Care Medicine Disease Outbreaks law.invention law Internal medicine Intensive care medicine Humans Adenovirus infection Cross Infection Respiratory Distress Syndrome Respiratory distress Septic shock business.industry Respiratory disease Rhode Island Middle Aged medicine.disease Shock Septic Intensive care unit Surgery Pneumonia Female business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 157:645-649 |
| ISSN: | 1535-4970 1073-449X |
| Popis: | Eighteen cases of pneumonia developed during an outbreak of adenovirus infection in a chronic psychiatric care facility. The six patients most severely affected were admitted to the intensive care unit (ICU) at our institution. Four of these patients developed septic shock. We report the presentation, disease progression, and response to treatment of these patients. Clinical features consisted of high fever, nonproductive cough, and dense lower lobe infiltrates. Laboratory abnormalities included transient fall in white blood cell and platelet counts, and elevations of transaminases, lactate dehydrogenase (LDH), and creatinine phosphokinase (CPK). Five patients were intubated for hypoxemia and four developed the acute respiratory distress syndrome (ARDS) and septic shock (mean cardiac output, 14.1 +/- 1.3 L/min; cardiac index, 6.4 +/- 0.4 L/min/min2; systemic vascular resistance, 326 +/- 107 dyne cm/s2). All patients recovered and were discharged back to the chronic care facility except for one patient with chronic renal failure who died 2 mo after admission. Adenovirus (serotype 35) was isolated from the respiratory secretions of five patients and antibody titers increased 6-fold in the other. These patients constitute the largest series of patients with ARDS and septic shock caused by adenovirus pneumonia and the first outbreak of multiple cases of adenovirus pneumonia in immunocompetent civilian adults occurring from a single source. |
| Databáze: | OpenAIRE |
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