Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
| Autor: | Adriana Miller, Henryk Kozlowski, Agnieszka Matera-Witkiewicz, Malgorzata Ostrowska, Slawomir Potocki, Aleksandra Hecel, Joanna Wątły, Kamila Stokowa-Sołtys, Alicia Domínguez-Martín, Dorota Dudek, Magdalena Rowińska-Żyrek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lcsh:Medicine lcsh:RS1-441 Pharmaceutical Science chemistry.chemical_element Zinc Review lcsh:Pharmacy and materia medica chloroquine 03 medical and health sciences chemistry.chemical_compound Chloroquine RNA polymerase Drug Discovery medicine 030304 developmental biology 0303 health sciences 030306 microbiology business.industry SARS-CoV-2 lcsh:R COVID-19 Hydroxychloroquine hydroxy- chloroquine Virology chemistry 2019-nCoV Molecular Medicine business Zn(II) ionophores medicine.drug |
| Zdroj: | Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Pharmaceuticals Digibug. Repositorio Institucional de la Universidad de Granada instname Pharmaceuticals, Vol 13, Iss 228, p 228 (2020) |
| ISSN: | 1424-8247 |
| Popis: | The authors would like to thank Agnieszka Michalczuk for providing us with her artistic vision of SARS-CoV-2. Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics. National Science Center, Poland UMO-2017/26/A/ST5/00363 UMO-2017/26/A/ST5/00364 |
| Databáze: | OpenAIRE |
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