PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update

Autor:	José Eduardo Adelino, Paula Sandrin-Garcia, Sergio Crovella, Suelen Cristina de Lima, Jaqueline de Azevêdo Silva
Přispěvatelé:	de Lima, Suelen Cristina, Adelino, José Eduardo, Crovella, Sergio, de Azevedo Silva, Jaqueline, Sandrin-Garcia, Paula
Rok vydání:	2017
Předmět:	0301 basic medicine Genotype Immunology SLE Biology Polymorphism Single Nucleotide polymorphism PTPN22 03 medical and health sciences 0302 clinical medicine Population Groups Genetic model Odds Ratio Humans Lupus Erythematosus Systemic Immunology and Allergy Meta-analysi Genetic Predisposition to Disease Allele Alleles Genetic Association Studies Genetic association 030203 arthritis & rheumatology 1858C > T Protein Tyrosine Phosphatase Non-Receptor Type 22 Odds ratio Meta-analysis 030104 developmental biology Genetic marker Publication Bias
Zdroj:	Autoimmunity. 50:428-434
ISSN:	1607-842X 0891-6934
Popis:	Studies performed in the past years showed PTNP22 1858 C > T (rs2476601) polymorphism as associated with systemic lupus erythematosus susceptibility, although conflicting findings are still found. In this context, a powerful statistical study, such as meta-analysis, is necessary to establish a consensus. The aim of this study was to evaluate association studies between the PTPN22 1858 C > T polymorphism and SLE by a meta-analysis update, including three recently published studies in the last three years. A total of 3868 SLE patients and 7458 healthy individuals were considered herein, enclosing 19 studies from Asian, American, European and Latin ethnic groups. Odds ratio (OR) was performed for allelic, dominant and recessive genetic models. Statistically significant association was found between the PTPN22 1858 C > T polymorphism and susceptibility to SLE in all inheritance models. Allelic genetic model data (OR = 1.54, 95% confidence interval (CI) = 1.38-1.72, p value=.000) shows that T allele confers increased SLE susceptibility. As well as recessive genetic model (OR = 2.04, 95% CI = 1.09-3.82, p value = .030) for T/T genotype. Instead, dominant genetic model shows that C/C genotype confers lower susceptibility for SLE development (OR = 0.62, 95% CI = 0.54-0.72, p value = .000). In addition, we provided an ethnicity-derived meta-analysis. The results showed association in Caucasian (OR = 1.47, p value = .000) and Latin (OR = 2.41, p value = .000) ethnic groups. However, rs2476601 polymorphism is not associated nor in Asian (OR= 1.31; p value = .54) and African (OR = 2.04; p value=.22) populations. In conclusion, present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc0a6f35872af841623a5dcf2dd1886 https://doi.org/10.1080/08916934.2017.1385774 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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