Long-Term Monitoring of the Antibody Response to a SARS-CoV-2 Infection
| Autor: | Robin Šín, Ladislav Pecen, Dalibor Sedláček, Petr Pazdiora, Vaclav Simanek, David Slouka, Hana Řezáčková, Ondřej Topolčan, Radek Kucera, Monika Bludovská, Karel Fajfrlík |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Clinical Biochemistry Gastroenterology Article time period R5-920 Internal medicine antibody Medicine immunoassay biology medicine.diagnostic_test business.industry SARS-CoV-2 COVID-19 Antibody production Antibody response Long term monitoring Immunoassay Cohort biology.protein serological diagnostics Antibody business nucleocapsid protein |
| Zdroj: | Diagnostics Diagnostics, Vol 11, Iss 1915, p 1915 (2021) Volume 11 Issue 10 |
| ISSN: | 2075-4418 |
| Popis: | A group of 110 patients from the West Bohemian region who had been infected with COVID-19 was monitored for the purposes of this study. We focused on cases of mild or moderate COVID-19 statistically the most likely to occur. Day zero was defined as the day on which a positive PCR test was first established. The mean length of observation was 6.5 months, the maximum length 12 months. The first blood samples were taken from a smaller cohort during the 1–3 months following the first positive PCR test. We assumed that SARS-CoV-2 antibodies would be present during this period and therefore a limited number of samples were taken for the purpose of detecting antibodies. More samples were collected, starting 4 months after the first positive PCR test. A subsequent set of blood samples were drawn, mostly 6 months after the first ones. Our study confirmed the presence of total IgG SARS-CoV-2 antibodies up to 1 year after the onset of the disease. The peak of antibody production was observed in the third month after the first positive PCR test. A mathematical estimate of the median duration of antibody positivity was calculated to be 18 months from the onset of the COVID-19 infection. |
| Databáze: | OpenAIRE |
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