Combination of TRP channel dietary agonists induces energy expending and glucose utilizing phenotype in HFD-fed mice
| Autor: | Mahendra Bishnoi, Jasleen Kaur, Vibhu Kumar, Pragyanshu Khare, Anurag Kuhad, Neha Mahajan, Kanthi Kiran Kondepudi, Rupam Kumar Bhunia, Vijay Kumar, Sadiah Shafi, Sanjay Kumar Bhadada |
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| Rok vydání: | 2021 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Adipose tissue White adipose tissue Diet High-Fat Mice chemistry.chemical_compound Transient Receptor Potential Channels Insulin resistance Internal medicine Brown adipose tissue TRPM8 medicine Animals Glucose homeostasis Acrolein Nutrition and Dietetics food and beverages medicine.disease Mice Inbred C57BL Disease Models Animal Menthol Phenotype Endocrinology medicine.anatomical_structure chemistry Capsaicin Energy Metabolism |
| Zdroj: | International Journal of Obesity. 46:153-161 |
| ISSN: | 1476-5497 0307-0565 |
| Popis: | Background Bioactive dietary constituents activating Transient receptor potential (TRP) channels have emerged as promising candidates for the prevention of metabolic disorders. Objective The present study is an attempt to evaluate anti-obesity potential of a dietary TRP-based tri-agonist, combination of sub-effective doses of capsaicin (TRPV1 agonist), menthol (TRPM8 agonist), and cinnamaldehyde (TRPA1 agonist) in high-fat diet (HFD)-fed mice. Design Male C57BL/6 J mice divided into three groups (n = 8), were fed on normal pellet diet (NPD), or high-fat diet (HFD) (60% energy by fat) and HFD + CB (combination of capsaicin 0.4 mg/Kg, menthol 20 mg/Kg, and cinnamaldehyde 2 mg/Kg; p.o) for 12 weeks. Effects on HFD-induced weight gain, biochemical, histological and genomic changes in the WAT, BAT, liver and hypothalamus tissues were studied. Results Administration of tri-agonist prevented HFD-induced increase in weight gain, improved altered morphometric parameters, glucose homeostasis, and adipose tissue hypertrophy. Tri-agonist supplementation was found to induce browning of white adipose tissue and promote brown adipose tissue activation. Enhanced glucose utilization and prevention of lipid accumulation and insulin resistance in the liver was observed in mice supplemented with a tri-agonist. Conclusion The present work provides evidence that the new approach based on combination of sub-effective doses of TRP channel agonists (TRI-AGONIST) can be employed to develop concept-based functional food for therapeutic and preventive strategies against HFD-associated pathological complications. |
| Databáze: | OpenAIRE |
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