The antileukoprotease secretory leukocyte protease inhibitor (SLPI) and its role in the prevention of HPV-infections in head and neck squamous cell carcinoma
| Autor: | Maximilian P. Gebhard, Christoph Röcken, Tibor Görögh, Rainald Knecht, Elgar Susanne Quabius, Florian Hoppe, Achim G. Beule, Petra Ambrosch, Martin Durisin, Matthias Evert, Markus Hoffmann, Attila Ovari, Anna S. Hoffmann, Jürgen Hedderich, Gerrit S. Fischer, Steffen Maune |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Cancer Research Biology stomatognathic system medicine Humans Secretory Leukocyte Peptidase Inhibitor Protease inhibitor (pharmacology) Inverse correlation Papillomaviridae Annexin A2 Aged Aged 80 and over Squamous Cell Carcinoma of Head and Neck Papillomavirus Infections Middle Aged medicine.disease Head and neck squamous-cell carcinoma Oncology Head and Neck Neoplasms Immunology Carcinoma Squamous Cell Female ANTILEUKOPROTEASE SLPI |
| Zdroj: | Cancer Letters. 357:339-345 |
| ISSN: | 0304-3835 |
| Popis: | Recently, we demonstrated a significant inverse correlation between HPV-infection and SLPI-expression suggesting that SLPI protects against HPV-infection of HNSCC. Here we analyzed in a single lab setting 307 formalin-fixed paraffin-embedded HNSCC cases (tonsillar n = 135; non-tonsillar: n = 172) from eight health care centers. Samples were analyzed for SLPI gene- and protein-expression. Annexin A2, its heterotetramer A2t, putatively facilitating HPV- and SLPI-cell entry, was measured to study the correlation between SLPI and annexin A2. Data were correlated with tobacco consumption and HPV-status. Overall, HPV-DNA prevalence was 23.5% (72/307); attributed to: 43.7% (59/135) tonsillar and 7.6% (13/172) non-tonsillar cases. Smoking resulted in 6.44-fold increased and HPV-infection in 3.46-fold decreased SLPI-gene expression in all HNSCC with similar significant results obtained in tonsillar and non-tonsillar SCC separately. Correlating annexin A2- and SLPI-gene expression showed a significant surplus of annexin A2 in HPV-positive tumors (4.21× more annexin A2) and 6.72× more annexin A2 than SLPI in nonsmokers in all HNSCCs and similar significant results for both tumor entities separately. The surplus of annexin A2 in non-smokers and HPV-positive patients supports our hypothesis that decreased SLPI levels facilitate HPV-infection i.e., increased SLPI-expression may protect against HPV-infection of tonsillar and non-tonsillar SCC. |
| Databáze: | OpenAIRE |
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