Circulating Non-Coding RNAs as a Signature of Autism Spectrum Disorder Symptomatology
| Autor: | Ahmed Elsayed, Salam Salloum-Asfar, Saba El-Hag, Sara A. Abdulla |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Adolescent diagnosis QH301-705.5 Autism Spectrum Disorder autism spectrum disorders lncRNAs Coding (therapy) Bioinformatics Catalysis Article Inorganic Chemistry Neurodevelopmental disorder microRNA mental disorders Medicine Humans Physical and Theoretical Chemistry Small nucleolar RNA Biology (General) Y-RNAs Child Molecular Biology QD1-999 Spectroscopy plasma business.industry Organic Chemistry ncRNAs General Medicine medicine.disease tRNAs Computer Science Applications snoRNAs Chemistry Mild symptoms Autism spectrum disorder piRNAs Clinical diagnosis Child Preschool Cohort miRNAs RNA Small Untranslated Female RNA Long Noncoding business Cell-Free Nucleic Acids Biomarkers |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 6549, p 6549 (2021) International Journal of Molecular Sciences Volume 22 Issue 12 |
| ISSN: | 1422-0067 |
| Popis: | Autism spectrum disorder (ASD) is a multifaced neurodevelopmental disorder that becomes apparent during early childhood development. The complexity of ASD makes clinically diagnosing the condition difficult. Consequently, by identifying the biomarkers associated with ASD severity and combining them with clinical diagnosis, one may better factionalize within the spectrum and devise more targeted therapeutic strategies. Currently, there are no reliable biomarkers that can be used for precise ASD diagnosis. Consequently, our pilot experimental cohort was subdivided into three groups: healthy controls, individuals those that express severe symptoms of ASD, and individuals that exhibit mild symptoms of ASD. Using next-generation sequencing, we were able to identify several circulating non-coding RNAs (cir-ncRNAs) in plasma. To the best of our knowledge, this study is the first to show that miRNAs, piRNAs, snoRNAs, Y-RNAs, tRNAs, and lncRNAs are stably expressed in plasma. Our data identify cir-ncRNAs that are specific to ASD. Furthermore, several of the identified cir-ncRNAs were explicitly associated with either the severe or mild groups. Hence, our findings suggest that cir-ncRNAs have the potential to be utilized as objective diagnostic biomarkers and clinical targets. |
| Databáze: | OpenAIRE |
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