The Heterosexual HIV Type 1 Epidemic in Papua New Guinea Is Dominated by Subtype C
| Autor: | Robert Oelrichs, Kim Wilson, Claire Ryan, Janet Gare, Suzanne M. Crowe, John C. Reeder |
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| Rok vydání: | 2007 |
| Předmět: |
Molecular Sequence Data
Immunology Hiv epidemic Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause Genes env Disease Outbreaks Papua New Guinea Virology parasitic diseases Pandemic East africa medicine Humans Heterosexuality Phylogeny Phylogenetic tree New guinea biology.organism_classification Infectious Diseases DNA Viral Lentivirus HIV-1 |
| Zdroj: | AIDS Research and Human Retroviruses. 23:941-944 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | Papua New Guinea is in the midst of a generalized HIV epidemic. As part of a larger behavioral survey aiming to further characterize the HIV epidemic occurring in PNG, samples were collected from 1175 participants from seven different provinces. Seventy-one (6%) of these samples were HIV-1 positive, and 35 (49%) successfully underwent a double nested RT-PCR that was designed to amplify the C2-V4 region of the HIV-1 envelope. Sequence analysis showed that 33 (94%) samples were subtype C and the remaining 2 (6%) were subtype B. Further phylogenetic analysis demonstrated that there was no province-specific clustering among the samples and that within the global pandemic, PNG subtype C isolates most closely resembled those from East Africa. |
| Databáze: | OpenAIRE |
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