Associations of adult‐attained height and early life energy restriction with postmenopausal breast cancer risk according to estrogen and progesterone receptor status
| Autor: | Leo J. Schouten, Colinda C. J. M. Simons, Piet A. van den Brandt, Matty P. Weijenberg, Bas A.J. Verhage, Nadine S M Offermans, Rachel J. J. Elands |
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| Přispěvatelé: | RS: GROW - R1 - Prevention, Promovendi ODB, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care |
| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
breast cancer epidemiology BIRTH medicine.drug_class NETHERLANDS CHILDHOOD Physiology Breast Neoplasms 03 medical and health sciences AGE 0302 clinical medicine Breast cancer Risk Factors Surveys and Questionnaires FAMINE Progesterone receptor Humans estrogen receptor status Medicine WORLD-WAR-II adult-attained height Prospective cohort study progesterone receptor status Estrogen Receptor Status Aged CONSEQUENCES business.industry energy restriction Hazard ratio Feeding Behavior Middle Aged Progesterone Receptor Status medicine.disease Body Height Postmenopause Receptors Estrogen PROSPECTIVE COHORT Oncology Estrogen 030220 oncology & carcinogenesis GROWTH Female WEIGHT Energy Intake Food Deprivation Receptors Progesterone business Follow-Up Studies Cohort study |
| Zdroj: | International Journal of Cancer, 144(8), 1844-1857. Wiley |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.31890 |
| Popis: | Adult-attained height is a marker for underlying mechanisms, such as cell growth, that may also influence postmenopausal breast cancer (BC) risk, perhaps specifically hormone-sensitive BC subtypes. Early life energy restriction may inhibit these mechanisms, resulting in shorter height and a reduced postmenopausal BC risk. Women (62,573) from the Netherlands Cohort Study completed a self-administered questionnaire in 1986 when 55-69 years old, and were followed-up for 20.3 years (case-cohort: N-subcohort = 2,438; N-cases = 3,354). Cox multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) were estimated for BC risk overall and by estrogen and progesterone receptor subtypes in relation to height and early life energy restriction during the Hunger Winter, War Years, and Economic Depression. Although energy restriction can only influence longitudinal growth in women exposed before and/or during the growth spurt, it may also influence BC risk when occurring after the growth spurt, possibly through different growth processes. Therefore, Cox analyses were additionally conducted according to timing of energy restriction in relation to the growth spurt. Height was associated with an increased BC risk (HRper 5cm = 1.07, 95%CI:1.01-1.13), particularly hormone receptor-positive BC. Energy restriction before and/or during the growth spurt was associated with a decreased hormone receptor-positive BC risk. Energy restriction during the Hunger Winter increased the estrogen receptor-negative BC risk regardless of the timing of energy restriction. In conclusion, height and energy restriction before and/or during the growth spurt were both associated with hormone receptor-positive BC risk, in the direction as expected, indicating critical exposure windows for hormonal growth-related mechanisms. |
| Databáze: | OpenAIRE |
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