Circulating tumor cells in breast cancer at the diagnosis are associated with lymph node involvement, tumor size and negative ER status
| Autor: | Maria Pia Pistillo, Vincenzo Fontana, Anna Morabito, Franco Fedeli, Maria Cristiana Franceschini, P. Ferro, B. Bacigalupo, Silvio Roncella, Paolo Dessanti, D. Gianquinto |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology biology Tumor size business.industry Biochemistry (medical) Plant Science medicine.disease circulating tumour cells human mammaglobin RT-PCR General Biochemistry Genetics and Molecular Biology Peripheral blood medicine.anatomical_structure Mammaglobin Breast cancer Circulating tumor cell Real-time polymerase chain reaction lcsh:Biology (General) Tumour size Internal medicine medicine biology.protein business lcsh:QH301-705.5 Lymph node |
| Zdroj: | Journal of Biological Research, Vol 84, Iss 1 (2011) |
| ISSN: | 1826-8838 |
| DOI: | 10.4081/jbr.2011.4643 |
| Popis: | We investigated the association of circulating tumor cells (CTC) with poor prognostic markers in breast cancer (BC) at time of diagnosis. Peripheral blood (PB) samples from 190 patients with invasive BC, 12 patients with in situ BC, before theraphy and/or surgery, and 330 from patients without BC were tested for CTCs by RT-PCR for human mammaglobin (hMAM). hMAM was expressed only in PB of invasive BC (9.5%) and a significant correlation was found between CTCs with lymph node involvement, tumour size and negative ER. We conclude that CTC detention in invasive BC may be an additional poor prognostic indicator. |
| Databáze: | OpenAIRE |
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