Lipoprotein abnormalities in chronic kidney disease and renal transplantation
| Autor: | Maurizio Averna, Davide Noto, Rosalia Caldarella, Emilio Nardi, Carlo M. Barbagallo, Antonina Giammanco, Marcello Ciaccio, Angelo B. Cefalù |
|---|---|
| Přispěvatelé: | Barbagallo C.M., Cefalu A.B., Giammanco A., Noto D., Caldarella R., Ciaccio M., Averna M., Nardi E. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lipoproteins 030232 urology & nephrology Disease Review 030204 cardiovascular system & hematology urologic and male genital diseases Gastroenterology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine Chronic kidney disease medicine lcsh:Science Ecology Evolution Behavior and Systematics Kidney business.industry Hypertriglyceridemia Paleontology medicine.disease Cardiovascular disease Lipids Uremia female genital diseases and pregnancy complications Transplantation medicine.anatomical_structure Space and Planetary Science lipids (amino acids peptides and proteins) lcsh:Q business Dyslipidemia Kidney disease Lipoprotein |
| Zdroj: | Life, Vol 11, Iss 315, p 315 (2021) Life |
| Popis: | Chronic kidney disease (CKD) is one of the most important risk factors for cardiovascular disease (CVD). Despite the kidney having no direct implications for lipoproteins metabolism, advanced CKD dyslipidemia is usually present in patients with CKD, and the frequent lipid and lipoprotein alterations occurring in these patients play a role of primary importance in the development of CVD. Although hypertriglyceridemia is the main disorder, a number of lipoprotein abnormalities occur in these patients. Different enzymes pathways and proteins involved in lipoprotein metabolism are impaired in CKD. In addition, treatment of uremia may modify the expression of lipoprotein pattern as well as determine acute changes. In renal transplantation recipients, the main lipid alteration is hypercholesterolemia, while hypertriglyceridemia is less pronounced. In this review we have analyzed lipid and lipoprotein disturbances in CKD and also their relationship with progression of renal disease. Hypolipidemic treatments may also change the natural history of CVD in CKD patients and may represent important strategies in the management of CKD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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