Low vitamin D serum levels in diffuse systemic sclerosis: a correlation with worst quality of life and severe capillaroscopic findings
| Autor: | Eloisa Bonfa, Liliam Takayama, Percival D. Sampaio-Barros, Rosa Maria Rodrigues Pereira, Marilia M. Sampaio-Barros |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Quality of life
Pathology medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Vitamina D Physical examination Severity of Illness Index Gastroenterology Body Mass Index Microscopic Angioscopy Correlation Qualidade de vida 03 medical and health sciences 0302 clinical medicine Bone Density Surveys and Questionnaires Internal medicine Esclerose sistêmica Vitamin D and neurology Humans Medicine 030212 general & internal medicine Vitamin D General Environmental Science Nailfold Capillaroscopy 030203 arthritis & rheumatology Bone mineral medicine.diagnostic_test business.industry Capilaroscopia periungueal Autoantibody Vitamin D Deficiency Scleroderma Diffuse Quality of Life Nailfold capillaroscopy Systemic sclerosis General Earth and Planetary Sciences Female lcsh:RC925-935 business Body mass index |
| Zdroj: | Revista Brasileira de Reumatologia v.56 n.4 2016 Revista Brasileira de Reumatologia Sociedade Brasileira de Reumatologia (SBR) instacron:SBR Revista Brasileira de Reumatologia, Vol 56, Iss 4, Pp 337-344 |
| ISSN: | 2255-5021 |
| DOI: | 10.1016/j.rbre.2016.05.006 |
| Popis: | Objective: The aim of this study was to analyze the correlation of vitamin D levels with clinical parameters, bone mineral density (BMD), quality of life (QoL) and nailfold capillaroscopy (NC) in patients with diffuse systemic sclerosis (SSc). Methods: Thirty-eight female patients with diffuse SSc were analyzed regarding 25-hydroxyvitamin D (25OHD) serum levels. At inclusion, organ involvement, autoantibodies, modified Rodnan skin score (mRSS), Medsger Disease Severity Index (MDSI), body mass index (BMI), BMD, NC, Short-Form-36 Questionnaire (SF-36), and Health Assessment Questionnaire (HAQ), were performed through a standardized interview, physical examination and electronic chart review. Results: Mean 25OHD serum level was 20.66 ± 8.20 ng/mL. Eleven percent of the patients had 25OHD levels ≤10 ng/mL, 50% ≤20 ng/mL and 87% ≤30 ng/mL. Vitamin D serum levels were positively correlated with BMI (r = 0.338, p = 0.038), BMD-total femur (r = 0.340, p = 0.037), BMD-femoral neck (r = 0.384, p = 0.017), SF-36-Vitality (r = 0.385, p = 0.017), SF-36-Social Function (r = 0.320, p = 0.050), SF-36-Emotional Role (r = 0.321, p = 0.049) and SF-36-Mental Health (r = 0.531, p = 0.0006) and were negatively correlated with HAQ-Reach (r = −0.328, p = 0.044) and HAQ-Grip Strength (r = −0.331, p = 0.042). A negative correlation with NC-diffuse devascularization (p = 0.029) and NC-avascular area (p = 0.033) was also observed. Conclusion: The present study provides novel evidence demonstrating that low levels of 25OHD have a negative impact in diffuse SSc QoL and further studies are needed to define whether vitamin D supplementation can improve health related QoL in these patients. The additional observation of a correlation with severe NC alterations suggests a possible role of 25OHD in the underlying SSc vascular involvement. |
| Databáze: | OpenAIRE |
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