The center of the emotional universe: Alcohol, stress, and CRF1 amygdala circuitry
| Autor: | Melissa A. Herman, Abigail E. Agoglia |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Health (social science) Future studies Corticotropin-Releasing Hormone Alcohol Anxiety Toxicology Receptors Corticotropin-Releasing Hormone Biochemistry Amygdala Article Corticotropin-releasing hormone receptor 1 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Neural Pathways medicine Humans CRF Receptor General Medicine Amygdala nuclei medicine.disease Comorbidity Alcoholism 030104 developmental biology medicine.anatomical_structure Neurology chemistry medicine.symptom Psychology Neuroscience Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Alcohol. 72:61-73 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/j.alcohol.2018.03.009 |
| Popis: | The commonalities between different phases of stress and alcohol use as well as the high comorbidity between alcohol use disorders (AUDs) and anxiety disorders suggest common underlying cellular mechanisms governing the rewarding and aversive aspects of these related conditions. As an integrative center that assigns emotional salience to a wide variety of internal and external stimuli, the amygdala complex plays a major role in how alcohol and stress influence cellular physiology to produce disordered behavior. Previous work has illustrated the broad role of the amygdala in alcohol, stress, and anxiety. However, the challenge of current and future studies is to identify the specific dysregulations that occur within distinct amygdala circuits and subpopulations and the commonalities between these alterations in each disorder, with the long-term goal of identifying potential targets for therapeutic intervention. Specific intra-amygdala circuits and cell type-specific subpopulations are emerging as critical targets for stress- and alcohol-induced plasticity, chief among them the corticotropin releasing factor (CRF) and CRF receptor 1 (CRF1) system. CRF and CRF1 have been implicated in the effects of alcohol in several amygdala nuclei, including the basolateral (BLA) and central amygdala (CeA); however, the precise circuitry involved in these effects and the role of these circuits in stress and anxiety are only beginning to be understood. |
| Databáze: | OpenAIRE |
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