A Chiral Phenanthroline Ligand with a Hydrogen-Bonding Site: Application to the Enantioselective Amination of Methylene Groups

Autor:	Thorsten Bach, Christian Jandl, Rajasekar Reddy Annapureddy
Rok vydání:	2020
Předmět:	Hydrogen bond Ligand Chemistry Phenanthroline Enantioselective synthesis General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Methylene Amination
Zdroj:	Journal of the American Chemical Society. 142:7374-7378
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.0c02803
Popis:	A silver-catalyzed amination is reported that occurs at the aliphatic C3-substituent of various quinolones and pyridones. The C-H amination reaction proceeded with high site- and enantioselectivity (14 examples, 83-97% ee). The key to its success is the use of a chiral phenanthroline ligand that is attached via an ethynyl linker to the 8-position of octahydro-1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cba42d42cbfd45e3ed4c9c68cd791a6 https://doi.org/10.1021/jacs.0c02803 Zobrazit plný text záznamu