Multiparametric Gd-EOB-DTPA magnetic resonance in diagnosis of HCC: dynamic study, hepatobiliary phase, and diffusion-weighted imaging compared to histology after orthotopic liver transplantation
| Autor: | Maria Carla Cassinis, Ezio David, Riccardo Faletti, Giovanni Gandini, Paolo Fonio, Luca Jacopo Pavan, Alessandro Rapellino, Laura Bergamasco |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Carcinoma Hepatocellular Urology medicine.medical_treatment Contrast Media Liver transplantation Chronic liver disease Gastroenterology Sensitivity and Specificity Internal medicine medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Postoperative Period Grading (tumors) Aged Retrospective Studies Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Liver Neoplasms Magnetic resonance imaging General Medicine Hepatology Middle Aged medicine.disease Image Enhancement Magnetic Resonance Imaging Liver Transplantation Diffusion Magnetic Resonance Imaging Liver Hepatocellular carcinoma Preoperative Period Female Neoplasm Grading business Diffusion MRI |
| Popis: | To evaluate Gd-EOB-DTPA-enhanced magnetic resonance (MR) performance during dynamic (DYN) phases, hepatobiliary (HB) phase and diffusion-weighted imaging (DWI) compared with pathological findings in patients undergoing orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) associated with different conditions, such as stage of chronic liver disease, histological grading, nodule size, and occurrence of previous treatments. Retrospective analysis of 64 nodules reported as HCC at pathological analysis on 28 explanted livers, examined about 3 months before OLT using a 1.5 T device and 16 channels array after intravenous GD-EOB-DTPA injection. Lesions features and hepatic functional values were recorded for each patient. Two radiologists performed in consensus the analysis of nodules on DYN, HB, and DWI. MR findings were compared with those of pathological anatomy. Diagnostic indicators were calculated for each technique. DYN and HB showed no statistically significant difference in sensitivity (88% and 98%, respectively), diagnostic accuracy (90.6% and 99.9%), and specificity (both 100%), for all Child-Pugh scores, gradings, sizes, and presence or absence of previous treatments. DWI had a statistically significant lower sensitivity compared to DYN (p = 0.001) and HB (p |
| Databáze: | OpenAIRE |
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