Interaction of neurocuprein with adrenaline
| Autor: | V.S. Gasparov, H. Ch. Buniatian, R.M. Nalbandyan |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Cytochrome
Epinephrine Reducing agent Biophysics Substantia nigra Nerve Tissue Proteins Biochemistry White matter Superoxide dismutase Norepinephrine Neurocuprein Structural Biology Mole Metalloproteins Genetics medicine Animals Drug Interactions Molecular Biology Brain Chemistry biology Chemistry Electron Spin Resonance Spectroscopy Cell Biology medicine.anatomical_structure biology.protein Amine gas treating Cattle Oxidation-Reduction Copper |
| Zdroj: | FEBS Letters. (1):37-39 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(79)80046-0 |
| Popis: | Neurocuprem is an acid coppercontaming protein of unknown physiological function isolated recently from grey and white matter of bovine brain as well as from brain areas of Substantia nigra and locus caeruleus [l-3]. The protein consists of one polypeptide cham with mol. wt 10 000 and contains 1 copper atom/ molecule. Neurocuprem has no amine oxldase, dopamine-fl-hydroxylase and superoxide dismutase activities. The protem does not exhibit activatmg or mhlbitory effects on cytochrome oxldase and superoxide dismutase [4] It was noted durmg the purification procedure that the protein remams reduced in the course of many stages. The prelimmary study has shown that the reducing agent is of catecholamme nature. In connection with this observation and m order to elucidate the possible role of neurocuprein it would be of interest to study the interaction of the protem with catecholammes and other neurotransmltters |
| Databáze: | OpenAIRE |
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