Clinicopathological characteristics of cutaneous malignant melanoma in patients at a tertiary hospital in Macaronesia. Survival as a function of locoregional prognostic factors per the American Joint Committee on Cancer
| Autor: | Cristian Casale, Benjamín González Delgado, José Carlos Martínez Cedrés, Noelia Hernández Hernández, Aitana Sánchez Barrios, Luisa Elena Gambra Michel, Jon Uña Gorospe, Antonio Perera Molinero, Ana Allende Riera, Sofía Garrido Ríos, Antonio Luis López Figueroa, Ricardo Fernández-de-Misa Cabrera, Alejandro Tébar Díaz, Miguel Ángel Cabrera Suárez |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Adolescent Sentinel lymph node Population Skin Pigmentation Kaplan-Meier Estimate Dermatology Gastroenterology Neoplasms Multiple Primary Tertiary Care Centers Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Skin Ulcer Atlantic Islands Humans Medicine Stage IIIC Stage (cooking) Hair Color education Melanoma Survival rate Aged Proportional Hazards Models Aged 80 and over education.field_of_study Eye Color Proportional hazards model business.industry Cancer Middle Aged medicine.disease Phototype Tumor Burden Survival Rate Spain Lymphatic Metastasis 030220 oncology & carcinogenesis Female business |
| Zdroj: | International Journal of Dermatology. 57:193-201 |
| ISSN: | 0011-9059 |
| Popis: | Background Despite suffering high ultraviolet radiation levels, few data on malignant melanoma (MM) in Macaronesia are available. Methods Observational study of cutaneous MM cases diagnosed during a period of 12 years at a tertiary hospital in Canary Islands. Results A total of 532 patients (female/male = 1.4) with an average age of 56 years were included; 5% developed more than one MM, and 7% reported family history of MM. Phototype II (43%), dark eyes (41%), and dark hair (41%) predominated. There was a lower frequency of light-colored hair and eyes in those born in the Canary Islands. The most frequent locations of MM were on the back for men (37%) and on the lower extremities for women (35%). Among the infiltrating tumors (83%), the (median) thickness was 1.07 mm (women, 0.90 mm; men, 1.21 mm). Anatomopathological ulceration (AU) and a mitotic rate ≥1 mitosis/mm2 (HMR) were recorded in 27% of patients. Patients with regional disease constituted 12% of the population. The most common stage was IA (34%). Melanoma-specific survival (MSSV) decreased significantly with thickness, presence of AU, HMR, and sentinel lymph node disease. These four variables were independent prognostic factors. The five-year MSSV varied between 100% (stage IA) and 39% (stage IIIC). Conclusions The characteristics of the patients were similar to those published in datasets from continental Europe, although the pigmentary features were darker in those originating from Macaronesia. The prognostic parameters described in the 7th edition of the American Joint Committee on Cancer (AJCC) independently predict MSSV in our patients. |
| Databáze: | OpenAIRE |
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