Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage

Autor: Rustam Al-Shahi Salman, Craig Anderson, Christophe Tzourio, Raf Brouns, David Werring, John Chalmers, Emma Heeley, Graeme Hankey, Serge Timsit, Qiang Li, Richard Lindley, Francesco Corea, Tiago Gregorio, Daniel Strbian, Emmanuel Touzé, Sylvie De Raedt, Mark Woodward, Andrea Zini, Sami Curtze, David Blacker, Ann De Smedt, C.J.M. Klijn, María del Mar Castellanos, Charlotte Cordonnier, Thompson Robinson, Markku Kaste, Laurent Billot, Candice Delcourt, Christian Stapf, Tissa Wijeratne, Victoria Haunton
Přispěvatelé: Neuroprotection & Neuromodulation, Neurology, Clinical sciences, Supporting clinical sciences, UZB Other, Physical Medicine and Rehabilitation, Vriendenkring VUB, Radiology
Rok vydání: 2016
Předmět:
Male
Pediatrics
Multivariate analysis
Warfarin/therapeutic use
030204 cardiovascular system & hematology
law.invention
0302 clinical medicine
Randomized controlled trial
law
risk factors
Hematoma
Disease Management
Middle Aged
Prognosis
Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
multivariate analysis
Neurology
Anticoagulants/therapeutic use
Hypertension
Cardiology
Female
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
Prognostic factor
03 medical and health sciences
Hematoma/diagnostic imaging
Hypertension/complications
Internal medicine
medicine
Humans
cardiovascular diseases
Antihypertensive Agents
Cerebral Hemorrhage
Aged
Intracerebral hemorrhage
Antihypertensive Agents/therapeutic use
Stroke scale
business.industry
Warfarin
Anticoagulants
medicine.disease
Cerebral Hemorrhage/complications
Blood pressure
Logistic Models
Neurology (clinical)
business
aged
80 and over
Tomography
X-Ray Computed
030217 neurology & neurosurgery
Zdroj: Cerebrovascular Diseases, 41, 80-6
Cerebrovascular Diseases, 41, 1-2, pp. 80-6
ISSN: 1015-9770
Popis: Background: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP Results: Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049). Conclusions: The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.
Databáze: OpenAIRE
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