Joint amplitude and connectivity compensatory mechanisms in Parkinson's disease
| Autor: | Samantha J. Palmer, Martin J. McKeown, Junning Li, Zongjie Wang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Parkinson's disease Brain mapping Basal Ganglia Disability Evaluation Thalamus Neuroimaging Cerebellum Neural Pathways Basal ganglia Image Processing Computer-Assisted medicine Humans skin and connective tissue diseases Aged Brain Mapping Neuronal Plasticity Resting state fMRI General Neuroscience Motor Cortex Brain Parkinson Disease Signal Processing Computer-Assisted Middle Aged medicine.disease Adaptation Physiological Magnetic Resonance Imaging medicine.anatomical_structure Amplitude Female sense organs Nerve Net Primary motor cortex Psychology Neuroscience Motor cortex |
| Zdroj: | Neuroscience. 166:1110-1118 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2010.01.012 |
| Popis: | Neuroimaging studies in Parkinson's disease (PD) have previously demonstrated several regions of hypo- and hyper-activation during voluntary movement. How these patterns of amplitude changes at multiple discrete foci relate to changes within functional networks recruited by a given task is unclear. Changes in both amplitude and connectivity have both been individually shown within the striato-thalamo-cortical (STC) loop in PD, as well as other regions, most consistently in the cerebellum and primary motor cortex. We have previously shown overactivation of the cerebellum and motor cortex in PD subjects off medication during a visuo-motor tracking task performed at three frequencies. Here, we show that this change in activation amplitude is also accompanied by significant changes in functional connectivity between regions of interest (ROIs), with enhanced connectivity within the cerebello-thalamo-cortical (CTC) loop as well as increased inter-hemispheric communication between several basal ganglia structures. Although changes in activation amplitude were influenced by the frequency of movement performed in the tracking task, functional connectivity changes were robustly present across all three task frequencies performed, suggesting that functional connectivity analysis in PD may be a more sensitive means of detecting plastic changes which are relatively invariant to the particulars of the experimental task. Additionally, we demonstrate amplitude and connectivity changes in structures that are typically active during the resting state, or "default-mode," in PD. Unlike in STC/CTC loops, where the direction of change was the same for amplitude and connectivity, default-mode regions showed increased amplitude but decreased connectivity. Our results further support that the CTC is recruited in PD to compensate for dysfunctional basal ganglia circuits, and that this recruitment involves both amplitude and connectivity changes. The differing relationship between amplitude and connectivity changes within individual loops highlights the importance of jointly examining them in order to fully elucidate functional changes in Parkinson's disease. |
| Databáze: | OpenAIRE |
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