Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats
| Autor: | Noha N. Nassar, Muhammed A. Saad, Muhammed F. El-Yamany, Mohamed A. Hamzawy, S.M. Farrag |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Normal diet Ubiquinone Drug Compounding Atorvastatin medicine.medical_treatment Hyperlipidemias medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Vitamin E Rats Wistar General Pharmacology Toxicology and Pharmaceutics Coenzyme Q10 biology Anticholesteremic Agents Muscles Vitamins General Medicine Malondialdehyde Rats Oxidative Stress 030104 developmental biology Endocrinology Liver chemistry 030220 oncology & carcinogenesis biology.protein Nanoparticles lipids (amino acids peptides and proteins) Creatine kinase Oxidative stress medicine.drug Lipoprotein |
| Zdroj: | Life Sciences. 203:129-140 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2018.04.034 |
| Popis: | Aims Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E. Materials and methods Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants “reduced glutathione (GSH) and superoxide dismutase (SOD)” were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination. Key findings The antihyperlipidemic effect of statins was not altered when formulated as nanoparticles; albeit the former showed a prominent reduction in the liver and muscle enzymes and histopathological alterations together with a marked decline in the oxidative stress as compared to the free particulate form. These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.E. Significance Nanoparticulate formulation alleviated the statins induced liver and muscle damage especially when combined with CoQ10 and/or Vit.E. |
| Databáze: | OpenAIRE |
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