Anti-Fibrotic Activity of an Antimicrobial Peptide in a Drosophila Model
| Autor: | Stefan Baumgartner, Dilan Khalili, Ulrich Theopold, Christina Kalcher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Tissue transglutaminase
extracellular matrix Peptide Salivary Glands antimicrobial peptides Fibrosis Cell polarity medicine Animals Drosophila Proteins innate immunity Internal medicine Basement membrane chemistry.chemical_classification insect immunity Polarity (international relations) Oncogene biology Chemistry fibrosis medicine.disease RC31-1245 Cell biology medicine.anatomical_structure Drosophila melanogaster biology.protein Medicine Ectopic expression Drosophila Research Article |
| Zdroj: | Journal of Innate Immunity, Pp 1-15 (2021) J Innate Immun |
| Popis: | Fibrotic lesions accompany several pathological conditions including tumors. We show that expression of a dominant-active form of the Ras oncogene in Drosophila salivary glands (SGs) leads to redistribution of components of the basement membrane (BM) and fibrotic lesions. Similar to several types of mammalian fibrosis, the disturbed BM attracts clot components including insect transglutaminase and phenoloxidase. SG epithelial cells show reduced apico-basal polarity accompanied by a loss of secretory activity. Both the fibrotic lesions and the reduced cell polarity are alleviated by ectopic expression of the antimicrobial peptide Drosomycin (Drs), which also restores secretory activity of the SGs. In addition to ECM components, both Drs and F-actin localize to fibrotic lesions. |
| Databáze: | OpenAIRE |
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