Integrase Strand Transfer Inhibitors Play the Main Role in Greater Weight Gain Among Men With Acute and Early HIV Infection
| Autor: | Christy M. Anderson, Susan J. Little, Kuan-Sheng Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty antiretroviral therapy 030106 microbiology Human immunodeficiency virus (HIV) Integrase inhibitor integrase strand transfer inhibitor medicine.disease_cause Major Articles 03 medical and health sciences 0302 clinical medicine acute and early HIV Clinical Research Internal medicine medicine 030212 general & internal medicine Reverse-transcriptase inhibitor biology business.industry Weight change HIV Evaluation of treatments and therapeutic interventions weight gain Integrase Integrase strand transfer inhibitor AcademicSubjects/MED00290 Infectious Diseases Oncology 6.1 Pharmaceuticals biology.protein HIV/AIDS medicine.symptom Infection business Weight gain Cohort study medicine.drug |
| Zdroj: | Open forum infectious diseases, vol 8, iss 1 Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofaa619 |
| Popis: | BackgroundThe predictors of weight gain remain unclear in people with acute and early HIV infection (AEH).MethodsEligible antiretroviral-naïve men diagnosed with AEH from January 1, 2000, to December 31, 2019, were enrolled in an observational cohort study at the University California, San Diego. The study used multivariable mixed-effect linear regression models to analyze differences in the rate of weight gain over time between participants receiving early vs deferred antiretroviral therapy (ART) treatment, low vs high baseline CD4 count and HIV RNA, and different classes of ART.ResultsA total of 463 participants were identified, with mean CD4 cell count of 507 cells/μL and log HIV RNA of 5.0 copies/mL at study entry. There was no difference in the rate of weight gain between participants who did and did not receive ART within 96 weeks of incident HIV infection. Neither a baseline CD4 count of 100 000 copies/mL was a predictor of weight gain. Compared with persons taking non-nucleoside reverse transcriptase inhibitor–based regimens, those who received integrase strand transfer inhibitor (INSTI)–based regimens showed greater weight gain over time.ConclusionsNeither baseline CD4 count and HIV RNA nor early ART was associated with weight change in the first 96 weeks following incident HIV infection. Use of INSTI-based regimens represented a major driver of weight gain in men who initiated ART with relatively higher CD4 cell counts. |
| Databáze: | OpenAIRE |
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