The relationship between impulsive choice and impulsive action: a cross-species translational study
| Autor: | Jannemieke Ham, Thomas Lam, Anna E. Goudriaan, Dick J. Veltman, Lennard Kostelijk, Eco J. C. de Geus, Lonneke Weierink, Anton N. M. Schoffelmeer, N. Broos, Taco J. De Vries, Joost Wiskerke, Lianne Schmaal, Tommy Pattij, Wim van den Brink, Nicky Stoop |
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| Přispěvatelé: | Adult Psychiatry, ANS - Amsterdam Neuroscience, Other departments, Biological Psychology, Neuroscience Campus Amsterdam - Attention & Cognition, Anatomy and neurosciences, Psychiatry, NCA - Attention & Cognition |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Serial reaction time
Male medicine.medical_specialty Cognitive Neuroscience Decision Making lcsh:Medicine Stop signal Biology Impulsivity Atomoxetine Hydrochloride Choice Behavior Inhibitions Animal data Behavioral Neuroscience Young Adult Barratt Impulsiveness Scale Model Organisms Norepinephrine reuptake inhibitor Reward Species Specificity SDG 3 - Good Health and Well-being medicine Animals Humans lcsh:Science Psychiatry Multidisciplinary Propylamines lcsh:R Atomoxetine Animal Models Animal Cognition Rats Amphetamine Research Design Impulsive Behavior Rat lcsh:Q Self Report medicine.symptom Neuroscience medicine.drug Atomoxetine hydrochloride Research Article |
| Zdroj: | PLoS ONE, 7(5). Public Library of Science PLoS ONE Broos, N, Schmaal, L, Wiskerke, J, Kostelijk, L, Lam, T, Stoop, N, Weierink, L, Ham, J, de Geus, E J C, Schoffelmeer, A N M, van den Brink, W, Veltman, D J, de Vries, T J, Pattij, T & Goudriaan, A E 2012, ' The relationship between impulsive choice and impulsive action: a cross-species translational study ', PLoS ONE, vol. 7, no. 5, e36781, pp. e36781 . https://doi.org/10.1371/journal.pone.0036781 PLoS ONE, 7(5):e36781. Public Library of Science PLoS ONE, Vol 7, Iss 5, p e36781 (2012) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0036781 |
| Popis: | Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there is only limited evidence available on whether different measures of impulsivity represent largely unrelated aspects or a unitary construct. In a cross-species translational study, thirty rats were trained in impulsive choice (delayed reward task) and impulsive action (five-choice serial reaction time task) paradigms. The correlation between those measures was assessed during baseline performance and after pharmacological manipulations with the psychostimulant amphetamine and the norepinephrine reuptake inhibitor atomoxetine. In parallel, to validate the animal data, 101 human subjects performed analogous measures of impulsive choice (delay discounting task, DDT) and impulsive action (immediate and delayed memory task, IMT/DMT). Moreover, all subjects completed the Stop Signal Task (SST, as an additional measure of impulsive action) and filled out the Barratt impulsiveness scale (BIS-11). Correlations between DDT and IMT/DMT were determined and a principal component analysis was performed on all human measures of impulsivity. In both rats and humans measures of impulsive choice and impulsive action did not correlate. In rats the within-subject pharmacological effects of amphetamine and atomoxetine did not correlate between tasks, suggesting distinct underlying neural correlates. Furthermore, in humans, principal component analysis identified three independent factors: (1) self-reported impulsivity (BIS-11); (2) impulsive action (IMT/DMT and SST); (3) impulsive choice (DDT). This is the first study directly comparing aspects of impulsivity using a cross-species translational approach. The present data reveal the non-unitary nature of impulsivity on a behavioral and pharmacological level. Collectively, this warrants a stronger focus on the relative contribution of distinct forms of impulsivity in psychopathology. © 2012 Broos et al. |
| Databáze: | OpenAIRE |
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