Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task

Autor: Ofer Pasternak, Michael Dagan, Tamar Blumenfeld-Katzir, Yaniv Assaf
Rok vydání: 2011
Předmět:
Male
Central Nervous System
Cingulate cortex
Aging
Pathology
Anatomy and Physiology
lcsh:Medicine
Corpus callosum
Spatial memory
Diagnostic Radiology
Behavioral Neuroscience
Learning and Memory
0302 clinical medicine
lcsh:Science
0303 health sciences
Neuronal Plasticity
Multidisciplinary
Brain
Animal Models
Immunohistochemistry
Magnetic Resonance Imaging
medicine.anatomical_structure
Neurology
Medicine
Radiology
Research Article
Nervous System Physiology
medicine.medical_specialty
Neurophysiology
Neuroimaging
Biology
Neurological System
03 medical and health sciences
Model Organisms
Developmental Neuroscience
Memory
Neuroplasticity
medicine
Animals
Learning
Rats
Wistar
030304 developmental biology
Motor Systems
Dentate gyrus
lcsh:R
Animal Cognition
Rats
Neuroanatomy
Diffusion Magnetic Resonance Imaging
nervous system
Cellular Neuroscience
Synaptic plasticity
Rat
lcsh:Q
Molecular Neuroscience
Physiological Processes
Neuroscience
030217 neurology & neurosurgery
Synaptic Plasticity
Diffusion MRI
Zdroj: PLoS ONE, Vol 6, Iss 6, p e20678 (2011)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0020678
Popis: Background Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation (LTP). Although T1 and diffusion MRI have been used to study structural changes resulting from long-term training, the cellular basis of the findings obtained and their relationship to neuroplasticity are poorly understood. Methodology/Principal Finding Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task. We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus. Conclusion/Significance We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.
Databáze: OpenAIRE
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