Anti-arthritic effect of β-caryophyllene and its ameliorative role on methotrexate and/or leflunomide-induced side effects in arthritic rats

Autor: Abd El-Alim F. Abd El-Alim, Sawsan M A El-Sheikh, Azza A.A. Galal, Rehab G. El-Sayed, Nesma I. El-naseery
Rok vydání: 2019
Předmět:
Male
musculoskeletal diseases
0301 basic medicine
Antimetabolites
Antineoplastic
animal structures
Drug-Related Side Effects and Adverse Reactions
medicine.medical_treatment
Inflammatory arthritis
Arthritis
Pharmacology
medicine.disease_cause
030226 pharmacology & pharmacy
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Rats
Wistar
General Pharmacology
Toxicology and Pharmaceutics
skin and connective tissue diseases
Leflunomide
Polycyclic Sesquiterpenes
business.industry
Anti-Inflammatory Agents
Non-Steroidal
fungi
General Medicine
medicine.disease
Arthritis
Experimental
Rats
Methotrexate
030104 developmental biology
Rheumatoid arthritis
embryonic structures
Drug Therapy
Combination
Tumor necrosis factor alpha
business
Sesquiterpenes
Adjuvant
Immunosuppressive Agents
Oxidative stress
medicine.drug
Zdroj: Life Sciences. 233:116750
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2019.116750
Popis: Aim Rheumatoid arthritis (RA) is the most widespread inflammatory arthropathy, which causes severe disability. It is highly important to ameliorate the side effects caused by different drugs used to treat RA. Therefore, this study assessed the potential role of β-caryophyllene (BCP) in treating adjuvant-induced arthritis (AIA), increasing the efficacy of methotrexate (MTX) and/or leflunomide (LEF), and ameliorating their side effects. Material and methods AIA was induced in rats by injecting complete Freund's adjuvant. The rats were divided into different groups such as sham group; control group; monotherapy groups, including BCP (300 mg/kg), MTX (1 mg/kg), and LEF (10 mg/kg); and combined groups, including MTX + BCP, LEF + BCP, MTX + LEF, and MTX + LEF + BCP groups. Key findings Monotherapy with BCP or MTX or LEF as well as MTX + LEF significantly reduced paw thickness and arthritic index; the histopathological changes in hind paw joints were recovered; and oxidative stress and tumor necrosis factor-alpha (TNF-α) levels in arthritic rats were reduced. The co-administration of BCP and MTX and/or LEF significantly improved the therapeutic efficacy of MTX and/or LEF and significantly reduced the myelosuppressive and hepatotoxic effects of MTX and/or LEF. Taken together, BCP could be used with MTX and/or LEF for the treatment of RA to reduce the side effects of the drugs and increase their efficacy.
Databáze: OpenAIRE
Externí odkaz: