Use of Naloxone in 9-1-1 Patients without Respiratory Depression in Los Angeles County, California (USA)
| Autor: | Michael Levine, Caroline E. Thomas, Stephen Sanko, Clayton Kazan, Colin Jenkins, Marc Eckstein |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Emergency Medical Services
medicine.medical_specialty Respiratory rate Naloxone business.industry Narcotic Antagonists Retrospective cohort study Emergency Nursing Los Angeles Analgesics Opioid Opioid Interquartile range Emergency medicine Emergency Medicine medicine Emergency medical services Humans Drug Overdose Respiratory system Respiratory Insufficiency business Depression (differential diagnoses) Retrospective Studies medicine.drug |
| Zdroj: | Prehospital and Disaster Medicine. 36:543-546 |
| ISSN: | 1945-1938 1049-023X |
| Popis: | Introduction:Along with an increase in opioid deaths, there has been a desire to increase the accessibility of naloxone. However, in the absence of respiratory depression, naloxone is unlikely to be beneficial and may be deleterious if it precipitates withdrawal in individuals with central nervous system (CNS) depression due to non-opioid etiologies.Objective:The aim of this study was to evaluate how effective prehospital providers were in administering naloxone.Methods:This is a retrospective study of naloxone administration in two large urban Emergency Medical Service (EMS) systems. The proportion of patients who had a respiratory rate of at least 12 breaths per minute at the time of naloxone administration by prehospital providers was determined.Results:During the two-year study period, 2,580 patients who received naloxone by prehospital providers were identified. The median (interquartile range) respiratory rate prior to naloxone administration was 12 (6-16) breaths per minute. Using an a priori respiratory rate of under 12 breaths per minute to define respiratory depression, only 1,232 (47.8%; 95% CI, 50.3%-54.2%) subjects who received naloxone by prehospital providers had respiratory depression.Conclusion:This study showed that EMS providers in Los Angeles County, California (USA) frequently administered naloxone to individuals without respiratory depression. |
| Databáze: | OpenAIRE |
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