Frequency, Risk Factors, and Prognosis of Dehydration in Acute Stroke

Autor: Cortés-Vicente, Elena, Guisado-Alonso, Daniel, Delgado Mederos, Raquel, Camps-Renom, Pol, Prats-Sánchez, Luis Antonio, Martínez-Domeño, Alejandro, Martí-Fàbregas, Joan, Universitat Autònoma de Barcelona
Rok vydání: 2019
Předmět:
multivariate logistic regression analysis
age distribution
creatinine blood level
dysphagia
very elderly
030204 cardiovascular system & hematology
lcsh:RC346-429
Serum urea
chemistry.chemical_compound
disease marker
0302 clinical medicine
Modified Rankin Scale
gender
risk factors
Stroke
Original Research
clinical article
creatinine
risk assessment
stroke
National Institutes of Health Stroke Scale
aged
female
Neurology
risk factor
brain hemorrhage
disease severity
cerebrovascular accident
medicine.medical_specialty
urea
Article
03 medical and health sciences
male
urea blood level
Internal medicine
Rankin scale
medicine
cross-sectional study
Dehydration
human
Risk factor
lcsh:Neurology. Diseases of the nervous system
Acute stroke
Creatinine
business.industry
scoring system
dehydration
medicine.disease
brain ischemia
Risk factors
chemistry
Observational study
observational study
Neurology (clinical)
prognosis
business
030217 neurology & neurosurgery
Zdroj: Frontiers in Neurology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Frontiers in Neurology, Vol 10 (2019)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ISSN: 1664-2295
Popis: Objective: To determine the frequency, risk factors, and impact on the outcome of dehydration after stroke. Methods: In this cross-sectional observational study, we included prospectively and consecutively patients with ischemic and hemorrhagic stroke. The serum Urea/Creatinine ratio (U/C) was calculated at admission and 3 days after the stroke. Dehydration was defined as U/C>80. Patients were treated in accordance with the standard local hydration protocol. Demographic and clinical data were collected. Neurological severity was evaluated at admission according to the NIHSS score; functional outcome was assessed with the modified Rankin scale score (mRS) at discharge and 3 months after the stroke. Unfavorable outcome was defined as mRS > 2. Results: We evaluated 203 patients; 78.8% presented an ischemic stroke and 21.2% a hemorrhagic stroke. The mean age was 73.4 years ±12.9; 51.7% were men. Dehydration was detected in 18 patients (8.9%), nine patients at admission (4.5%), and nine patients (4.5%) at 3 days after the stroke. Female sex (OR 3.62, 95%CI 1.13–11.58, p = 0.03) and older age (OR 1.05, 95%CI 1–1.11, p = 0.048) were associated with a higher risk of dehydration. Dehydration was significantly associated with an unfavorable outcome at discharge (OR 5.16, 95%CI 1.45–18.25, p = 0.011), but the association was not significant at 3 months (OR 2.95, 95%CI 0.83–10.48, p = 0.095). Conclusion: Dehydration is a treatable risk factor of a poor functional outcome after stroke that is present in 9% of patients. Females and elders present a higher risk of dehydration. © Copyright © 2019 Cortés-Vicente, Guisado-Alonso, Delgado-Mederos, Camps-Renom, Prats-Sánchez, Martínez-Domeño and Martí-Fàbregas.
Databáze: OpenAIRE
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