Studies towards topical selective β2-adrenoceptor agonists with a long duration of action

Autor:	Thierry Bouyssou, Andreas Schnapp, Klaus Rudolf, Philipp Lustenberger, Christoph Hoenke, Ingo Konetzki
Rok vydání:	2009
Předmět:	Agonist medicine.drug_class Guinea Pigs Clinical Biochemistry Pharmaceutical Science Carboxamide Pharmacology Biochemistry Guinea pig chemistry.chemical_compound Ethanolamine Heart Rate In vivo Drug Discovery medicine Animals Humans Potency Adrenergic beta-2 Receptor Agonists Molecular Biology Chemistry Cellular Assay Organic Chemistry Asthma In vitro Bronchodilator Agents Adrenergic beta-1 Receptor Agonists Ethanolamines Molecular Medicine Receptors Adrenergic beta-2 Receptors Adrenergic beta-1
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:5237-5240
ISSN:	0960-894X
Popis:	β2-Adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in vitro and in vivo. The compounds exhibited a high potency in a functional cellular assay and a bronchoprotective effect in a guinea pig model which lasted over the complete study period of 5 h.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cac584f703ec1b31176bfcb7764c9c1 https://doi.org/10.1016/j.bmcl.2009.06.104 Zobrazit plný text záznamu Full Text from ScienceDirect