Evaluation of sedative, analgesic, physiological, and laboratory effects of two doses off medetomidine and xylazine in dromedary calves
| Autor: | Fattah Iranmanesh, Amir Saeed Samimi, Ehsanollah Sakhaee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Xylazine Camelus 040301 veterinary sciences medicine.drug_class Sedation medicine.medical_treatment Analgesic Conscious Sedation Pain 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030202 anesthesiology medicine Animals Hypnotics and Sedatives Saline Pharmacology Creatinine General Veterinary business.industry 04 agricultural and veterinary sciences Medetomidine chemistry Anesthesia Sedative Analysis of variance medicine.symptom Analgesia business medicine.drug |
| Zdroj: | Journal of veterinary pharmacology and therapeutics. 42(4) |
| ISSN: | 1365-2885 |
| Popis: | The present study aims to comparatively evaluate the effects of different doses of intravenous xylazine and medetomidine on sedation and antinociception scores, and physiological and laboratory parameters in dromedary calves. Thirty clinically healthy male dromedary calves 15 ± 2 weeks old and weighing 95 ± 5.5 kg were studied. Two groups received xylazine at low (0.2 mg/kg) and high (0.4 mg/kg) doses. Two groups received medetomidine at low (10 µg/kg) and high (20 µg/kg) doses. One group received normal saline. Sedation signs were scored using a 3-point scale. Analgesic effect was analyzed using pinpricks. Data were analyzed by one-way ANOVA and Mann-Whitney U-tests. Sedation and antinociception scores of the animals 1 hr after receiving the higher dose of xylazine and medetomidine were significantly higher than that of other groups. Compared with other studied groups, the animals receiving the higher dose of xylazine showed significantly higher potassium and creatinine serum levels after 24 hr. Doses as high as 0.4 mg/kg for xylazine and 20 µg/kg for medetomidine can be considered safe and useful for procedures associated with mild pain in dromedary calves. |
| Databáze: | OpenAIRE |
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