Human IgE does not bind to human FcRn
| Autor: | Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson |
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| Přispěvatelé: | AII - Inflammatory diseases, Landsteiner Laboratory, Graduate School |
| Rok vydání: | 2022 |
| Předmět: |
Immunoglobulin E/metabolism
Science Placenta Immunology Receptors Fc beta 2-Microglobulin/metabolism Biochemistry Article Pregnancy Receptors Placenta/metabolism Humans Maternal-Fetal Exchange Multidisciplinary Receptors Fc/metabolism Blood proteins Histocompatibility Antigens Class I Fc/metabolism Biological Transport Hydrogen-Ion Concentration Immunoglobulin E Surface Plasmon Resonance Histocompatibility Antigens Class I/metabolism Immunoglobulin G Immunoglobulin G/metabolism Medicine Female beta 2-Microglobulin Protein Binding |
| Zdroj: | Scientific Reports Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022) Scientific reports, 12(1):62. Nature Publishing Group |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-03852-1 |
| Popis: | The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens. Recent evidence suggests FcRn-mediated transplacental passage of IgE during pregnancy. However, direct interaction of FcRn and IgE was not investigated. Here, we compared binding of human IgE and IgG variants to recombinant soluble human FcRn with β2-microglobulin (sFcRn) in surface plasmon resonance (SPR) at pH 7.4 and pH 6.0. No interaction was found between human IgE and human sFcRn. These results imply that FcRn can only transport IgE indirectly, and thereby possibly transfer allergenic sensitivity from mother to fetus. |
| Databáze: | OpenAIRE |
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