Radiotherapy With or Without Surgery for Patients With Idiopathic Sclerosing Orbital Inflammation Refractory or Intolerant to Steroid Therapy
| Autor: | Yeon-Sil Kim, Mi-Ryeong Ryu, Jong Hoon Lee, Suk Woo Yang, Kyung Ji Lee, Won-Kyung Cho, Hong Seok Jang, Sang Nam Lee |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Inflammation Disease Cataracts Refractory Orbital Pseudotumor medicine Recurrent disease Exophthalmos Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies Salvage Therapy Radiation business.industry Remission Induction Radiotherapy Dosage Middle Aged medicine.disease Debulking Combined Modality Therapy Surgery Radiation therapy Treatment Outcome Steroid therapy Oncology Female Steroids medicine.symptom business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 84:52-58 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2011.11.031 |
| Popis: | Purpose To evaluate the outcomes of patients with idiopathic sclerosing orbital inflammation (ISOI) treated with radiotherapy with or without surgery. Methods and Materials We retrospectively reviewed 22 patients with histopathologically confirmed ISOI who had been refractory or intolerant to steroid therapy and treated with radiation with or without surgery. The radiation dose ranged from 20 to 40 Gy (median, 20 Gy) at 2 Gy per fraction. Presenting signs and treatment outcomes were assessed. Results Proptosis was the most common sign at presentation, seen in 19 (86.3%) patients, followed by restriction of extraocular movements in 10 (45.4%) patients. Response to radiotherapy was complete in 15 (68.1%) patients, partial in 3 (13.6%) patients, and none in 4 (18.2%) patients. At the median follow-up of 34 months, 14 (63.6%) patients had progression-free state of symptoms and signs, with the progression-free duration ranging from 3 to 75 months (median, 41.5 months), whereas 8 (36.4%) patients had recurrent or persistent disease although they had received radiotherapy. Of the 14 progression-free patients, 6 underwent a bimodality treatment of debulking surgery of ocular disease and radiotherapy. They had had no recurrent disease. Cataract was the most common late complications, and 2 patients experienced a Grade 3 cataract. Conclusion Our study suggests that for patients with ISOI who are refractory or intolerant to steroid therapy, 20 Gy of radiotherapy appears to be effective for the control of disease with acceptable complications, especially when it is combined with surgery. |
| Databáze: | OpenAIRE |
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