Effects of slightly acidic electrolysed drinking water on mice
| Autor: | Hideaki Inagaki, Kazumi Toida, Hidemi Kushima, Katsuhisa Ikeda, Takahiro Obata, Masami Kawagoe, Yukihisa Matsuda, Masayoshi Sato, Yoshiko Shibata |
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| Rok vydání: | 2011 |
| Předmět: |
Food intake
Hypochlorous acid Drinking Bacterial growth Body weight chemistry.chemical_compound Eating Mice Hand sanitizer parasitic diseases Animals Food science Aspartate Aminotransferases Alanine aminotransferase General Veterinary Chemistry Drinking Water Health condition Body Weight Alanine Transaminase Hydrogen Peroxide Viscera Biochemistry Residual chlorine Creatinine Animal Science and Zoology |
| Zdroj: | Laboratory animals. 45(4) |
| ISSN: | 1758-1117 |
| Popis: | Slightly acidic electrolysed (SAE) water is a sanitizer with strong bactericidal activity due to hypochlorous acid. We assessed the safety of SAE water as drinking water for mice at a 5 ppm total residual chlorine (TRC) concentration to examine the possibility of SAE water as a labour- and energy-saving alternative to sterile water. We provided SAE water or sterile water to mice for 12 weeks, during which time we recorded changes in body weight and weekly water and food intakes. At the end of the experiment, all of the subject animals were sacrificed to assess serum aspartate aminotransferase, alanine aminotransferase and creatinine levels and to examine the main organs histopathologically under a light microscope. In addition, we investigated the bacteria levels of both types of water. We found no difference in functional and morphological health condition indices between the groups. Compared with sterile water, SAE water had a relatively higher ability to suppress bacterial growth. We suggest that SAE water at 5 ppm TRC is a safe and useful alternative to sterile water for use as drinking water in laboratory animal facilities. |
| Databáze: | OpenAIRE |
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