Clinicopathologic predictors of survival in buccal squamous cell carcinoma
| Autor: | Daniel L. Price, Shahm W. Raslan, Jeffrey R. Janus, Lisa M. Marinelli, Andrea R. Collins, Tiffany Y. Chen, Eneida F. Vencio, Joaquin J. Garcia, John P. Marinelli, Kyriakos Chatzopoulos, Sotiris Sotiriou |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty Multivariate analysis Lymphovascular invasion Perineural invasion Disease Malignancy Gastroenterology Pathology and Forensic Medicine Surgical pathology 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Neoplasm Invasiveness Aged Neoplasm Staging Retrospective Studies Univariate analysis business.industry 030206 dentistry medicine.disease Prognosis Otorhinolaryngology 030220 oncology & carcinogenesis Cohort Carcinoma Squamous Cell Periodontics Mouth Neoplasms Oral Surgery Neoplasm Recurrence Local business |
| Zdroj: | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyREFERENCES. 49(9) |
| ISSN: | 1600-0714 |
| Popis: | BACKGROUND Buccal squamous cell carcinoma (SCC) is a locoregionally aggressive malignancy, representing a small subset of oral cancers in North America. We investigated the prognostic value of several clinicopathologic factors in a cohort of patients diagnosed with buccal SCC. METHODS Between years 1992 and 2017, 52 patients were diagnosed with conventional buccal SCC. Archival surgical pathology material was retrospectively reviewed for reportable findings according to the latest reporting guidelines published by the College of American Pathologists. Clinical data were obtained through chart review. RESULTS The majority of patients were of older age, current or past smokers, and without specific gender predilection. Most presented at a clinically advanced stage and were treated with surgery alone, or surgery followed by adjuvant radiotherapy. The tumor recurred in about 40% of patients, and almost half of the patients died from the disease by the end of the follow-up period. The worst pattern of invasion (WPOI) was associated with greater depth of invasion (DOI) (P = .031) and perineural invasion (P |
| Databáze: | OpenAIRE |
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