| Autor: |
Kazuo K. Kimura, Barbara Bartels, Harald G.O. Holck |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 35(12) |
| Popis: |
In parallel experiments six groups of 12 cats each were anesthetized with urethane and a like number with ether for injection with different dilutions of digitalis according to the U. S. P. XII method. The curves for urethane and for ether were parallel, indicating that the two methods of anesthesia gave results of about the same precision. The smallest lethal dose of digitalis has been calculated to result with 1.76 per cent of tincture of digitalis with either anesthetic. The lethal dose of digitalis was 6.5 per cent greater with urethane than with ether anesthesia; the difference is statistically significant. The slope of the line shows that an error of about 8 per cent exists between the extremes of the 13 to 19 injections permitted by the Pharmacopœia, due to change in concentration of tincture alone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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