Cardiomyocyte-specific loss of plasma membrane calcium ATPase 1 impacts cardiac rhythm and is associated with ventricular repolarisation dysfunction

Autor:	Claire Wilson, Nicholas Stafford, Min Zi, Alexandru Chelu, Barbara C. Niort, Yatong Li, Florence Baudoin, Sukhpal Prehar, Andrew W. Trafford, Elizabeth J. Cartwright
Rok vydání:	2022
Předmět:	Proteomics Mice Plasma Membrane Calcium-Transporting ATPases Ventricular Dysfunction Animals Arrhythmias Cardiac Calcium Myocytes Cardiac Cardiology and Cardiovascular Medicine Molecular Biology Genome-Wide Association Study
Zdroj:	Journal of Molecular and Cellular Cardiology. 172:41-51
ISSN:	0022-2828
Popis:	Plasma membrane calcium ATPase 1 (PMCA1, Atp2b1) is emerging as a key contributor to cardiac physiology, involved in calcium handling and myocardial signalling. In addition, genome wide association studies have associated PMCA1 in several areas of cardiovascular disease including hypertension and myocardial infarction. Here, we investigated the role of PMCA1 in basal cardiac function and heart rhythm stability. Cardiac structure, heart rhythm and arrhythmia susceptibility were assessed in a cardiomyocyte-specific PMCA1 deletion (PMCA1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca367321e1480a1e7f420eea409c924 https://doi.org/10.1016/j.yjmcc.2022.07.011 Zobrazit plný text záznamu Full Text from ScienceDirect