Regulation of Th1/Th2 and Th17/Treg by pDC/mDC imbalance in primary immune thrombocytopenia
| Autor: | Yang Liu, Lei Wang, Ying Liu, Xiujuan Wang, Kaile Zhang, Xinhong Guo, Xinyou Wang, Mingling Sun, Qinzhi Li, Wenxia Fan, Xiao Sui |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Th17 treg Myeloid T-Lymphocytes Regulatory General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Medicine Humans Transcription factor Original Research Purpura Thrombocytopenic Idiopathic business.industry Interleukin-17 Dendritic Cells Middle Aged Immune thrombocytopenia 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Leukocytes Mononuclear Th17 Cells Female business |
| Zdroj: | Exp Biol Med (Maywood) |
| Popis: | This study investigates the regulatory effect of plasmacytoid dendritic cells (pDC)/myeloid dendritic cells (mDC) imbalance on balance of Th1/Th2 and Th17/Treg in primary immune thrombocytopenia (ITP). A total of 30 untreated ITP patients and 20 healthy controls were recruited. Compared with healthy control, the pDC proportion of ITP patients was significantly reduced ( P = 0.004), while the mDC proportion was not significantly changed ( P = 0.681), resulting in a decrease in the pDC/mDC ratio ( P = 0.001). Additionally, compared with controls, serum levels of interleukin (IL)-6, IL-12, and IL-23 were increased in ITP patients ( P |
| Databáze: | OpenAIRE |
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