Metal–ligand–Lewis acid multi-cooperative catalysis: a step forward in the Conia-ene reaction

Autor:	Arnaud Clerc, Didier Bourissou, Blanca Martin-Vaca, Enrico Marelli, Nicolas Adet, Julien Monot
Rok vydání:	2021
Předmět:	010405 organic chemistry Chemistry Ligand General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis Metal visual_art visual_art.visual_art_medium Lewis acids and bases Ene reaction
Zdroj:	Chemical Science
ISSN:	2041-6520
DOI:	10.1039/d0sc05036a
Popis:	An original multi-cooperative catalytic approach was developed by combining metal–ligand cooperation and Lewis acid activation. The [(SCS)Pd]2 complex featuring a non-innocent indenediide-based ligand was found to be a very efficient and versatile catalyst for the Conia-ene reaction, when associated with Mg(OTf)2. The reaction operates at low catalytic loadings under mild conditions with HFIP as a co-solvent. It works with a variety of substrates, including those bearing internal alkynes. It displays complete 5-exo vs. 6-endo regio-selectivity. In addition, except for the highly congested tBu-substituent, the reaction occurs with high Z vs. E stereo-selectivity, making it synthetically useful and complementary to known catalysts. An original multi-cooperative catalytic approach was developed by combining metal–ligand cooperation and Lewis acid activation.
Databáze:	OpenAIRE
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