Structure based design: Novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors

Autor:	Jose G. Trevino, K. Krishnan, Yumee Koo, Louis E. Holland, Wonhwa Cho, Arun K. Ghosh, D. Eric Walters, Hanna Cho, Jim Buthod
Rok vydání:	1998
Předmět:	Models Molecular Stereochemistry medicine.drug_class Isostere medicine.medical_treatment Clinical Biochemistry Molecular Conformation Pharmaceutical Science Carboxamide Crystallography X-Ray Ligands Biochemistry Chemical synthesis Structure-Activity Relationship HIV Protease Ethers Cyclic Drug Discovery medicine Humans Structure–activity relationship HIV Protease Inhibitor Molecular Biology chemistry.chemical_classification Protease biology Organic Chemistry virus diseases Stereoisomerism HIV Protease Inhibitors Sulfonamide Kinetics chemistry Enzyme inhibitor Drug Design HIV-1 biology.protein Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:979-982
ISSN:	0960-894X
Popis:	A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca083a95e2ee85a6c0717a7b53401a9 https://doi.org/10.1016/s0960-894x(98)00139-5 Zobrazit plný text záznamu Full Text from ScienceDirect